Endothelin Antagonists and Skin Brightening

 

The skin lightening product market is continuing to gain momentum globally. Consequently, there is an increasing need for a new generation of skin care products with scientific basis that will give more promising results. At CoValence, our mission is to develop the highest scientific knowledge-based skin care products, therefore we are consistently utilizing and combining ingredients that trigger different functions in the skin.

Visible pigmentation of the skin, hair and eyes depends primarily on the functions of melanocytes, a very minor population of cells that specialize in the synthesis and distribution of the pigmented biopolymer melanin. The accurate migration, distribution, and functioning of melanoblasts/melanocytes determine the visible phenotype of organisms ranging from simple fungi to the most complex animal species.

In normal human skin, melanocytes maintain their constant population and steady melanogenic activity. But several external factors such as UV irradiation and chemical irritation enhance the proliferation and differentiation of melanocytes and subsequently lead to hyperpigmentation of the human skin. Each melanocyte contains five times more melanosomes in Asian skin than in Caucasian skin, and eight to ten times more melanosomes in dark skin compared with light skin. Endothelin-1 (ET-1) is a messenger protein produced by human keratinocyte acts as a strong cell multiplying (mitosis) agent on human melanocytes and plays an important role in ultra violet (UV) induced hyperpigmentation. Endothelin-1 (ET-1) has been reported to be expressed in human epidermis at both the gene and protein levels. ET-1 plays a pivotal role in ultraviolet B (UVB)-induced pigmentation due to its accentuated secretion after UVB irradiation and its function as a mitogen and as a melanogen for human melanocytes.

An Endothelin Antagonist (EA) is a compound that combines with the protein molecule embedded in the melanocyte membrane to inhibit the influence of endothelin protein toward melanin formation (melanogenesis), so that an instant and high efficiency skin lightening was achieved in human skin. The EA compounds normally don’t have any toxic or allergic symptoms towards human beings and possess increased penetrating ability due its low molecular weight (≥1000) nature. Endothelin antagonists are known to cause a four-times accelerated inhibition of the melanin synthesis compare to other plant based melonogenesis inhibitors. The EA compounds do not enter the melanosomes and cause cell cytoxicity to inhibit the tyrosinase or the oxidative processes. These compounds penetrate into deeper layers of the epidermis to inhibit endothelin protein, which is a safe method of skin lightening.

Endothelin Antagonist technology is a scientifically proven and safe method for human skin lightening.

Contact an Account Executive today to see how we can create a product, or two, using the advancement of EA technology for you.

(*) A product that uses EA technology is not considered an OTC drug unless there is a claim of ‘lightening’ the skin. A ‘brightening’ claim keeps the product within the boundaries of a Cosmeceutical, not a drug.

Tags: endothelin antagonist, lightening, melanocytes, pigmentation

Categories: SKINsider

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